Dr.Gayatri Dasari

Abstract

Study design: Case report
Background: Chronic progressive external ophthalmoplegia (CPEO) is a rare mitochondrial disorder characterized by progressive symmetric immobility of the eyes with ptosis, weakness of the orbicularis oculi, and spared pupils.
Case report: This is a case report of a 62-year-old male with bilateral ptosis, restricted eye movements, and a familial occurrence of CPEO in his mother and daughter. The patient had a history of cataract surgery and used crutch aphakic glasses. Clinical examination revealed bilateral ptosis, external ophthalmoplegia, aphakia, clear cornea, deep anterior chamber, brisk pupil reactions, and normal posterior segment.
Discussion: The familial occurrence of CPEO suggests a possible mitochondrial inheritance pattern, highlighting the role of genetic factors in the development of the disorder.
Conclusion: Further research is needed to uncover the specific mitochondrial DNA mutations involved and develop targeted therapeutic strategies.